Seasonal Immunity Study

Surrey Clinical Research Centre- Investigation into Seasonal Changes in Human Immune Function

Would you like to participate in one of our research projects looking into how our immune systems changes with the seasons? You can do this by joining a clinical study at our specialist centre in Guildford.

This study aims to characterise seasonal and daily rhythms in the immune system which might help us to understand what makes us susceptible to certain diseases at different times of year and the best time to receive immunisations.      Identification of seasonal rhythms in immunity could advance community medicine by allowing for seasonally-timed treatment and prevention. The Surrey Principal Investigator for this study is Professor Debra Skene.

The study will last approximately 12 months during which time there will be five visits to the centre. The first visit would be a screening visit to establish your eligibility for the study which will last around four hours. The next five visits will be residential stays at the centre lasting four days. During your stay we will be measuring your immune system, your sleep patterns and your circadian rhythms using blood tests and EEG electrodes.

Participant Requirements 

 

Healthy adults between 18 and 30 years old

Females of child bearing potential must be taking the combined oral contraceptive pill.

Be of white ethnicity and have lived in South England for majority of life

Not working rotating or night shifts

Agree to keep a constant sleep/wake cycle, with 6-9-hours in bed, as agreed with the research team, and report it.

Have a BMI of 19 to 28kg/m2.

 

Information 

 

Cohort 1 Visits:-

Visit 1 – Screening – Outpatient visit

Baseline visits 2a, 3a, 4a– Outpatient visit

Pre-residential stays – 14 day sleep measurements - Home

Visit 2b, 3b and 4b – Study visit – 3 night residential stay

 

Post-residential stays – 14 day sleep measurements – Home

Post-residential visits – 2c, 3c, 4c – Outpatient visit


Cohort 2 Visits:-

Visit 1 – Screening – Outpatient visit

Baseline visits 2a, 3a, 4a, 5a, 6a – Outpatient visit

Pre-residential stays – 14 day sleep measurements - Home

Visit 2b, 3b, 4b, 5b and 6b – Study visit – 3 night residential stay

Post-residential stays – 14 day sleep measurements – Home

Post-residential visits – 2c, 3c, 4c, 5c, 6c – Outpatient visit

Visit 
Date Description Location Duration
19 November 2018 Cohort 1 Visit 2A Surrey CRC Outpatient
3 December 2018 Cohort 1 Visit 2B Surrey CRC 3-4 days
20 December 2018 Cohort 1 Visit 2C Surrey CRC Outpatient
17 June 2019 Cohort 1 Visit 3 Surrey CRC 3-4 days
2 December 2019 Cohort 1 Visit 4 Surrey CRC 3-4 days
3 December 2018 Cohort 2 Visit 2A Surrey CRC Outpatient
16 December 2018 Cohort 2 Visit 2B Surrey CRC 3-4 days
3 January 2019 Cohort 2 Visit 2C Surrey CRC Outpatient
18 March 2019 Cohort 2 Visit 3 Surrey CRC 3-4 days
24 June 2019 Cohort 2 Visit 4 Surrey CRC 3-4 days
23 September 2019 Cohort 2 Visit 5 Surrey CRC 3-4 days
16 December 2019 Cohort 2 Visit 6 Surrey CRC 3-4 days
Inconvenience Allowance 

 

Cohort 1 - £1920.00

Cohort 2 - £3080.00

Interested in taking part? 

 

Already registered as a participant with us?

New participant application form

If you have already registered with us or have previously taken part in a study at the CRC please click "already registered" to express your interest. If you have not previously registered please click "new participant application form".

More Information? 

 

If you would like more information under no obligation, or are interested in taking part and wish to complete a telephone health screen, please contact the Clinical Research Recruitment team on: Freephone 0800 269 847, by email crc-recruitment@surrey.ac.uk.

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